Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | blood |
| Expression Pattern | up-regulated |
| Function Description | The expression of HOTAIR was significantly upregulated in the AML patients compared with the healthy controls, and markedly decreased in the patients post-treatment compared with pre-treatment. Moreover, high levels of HOTAIR were associated with higher white blood cell and BM blast counts, and lower hemoglobin and platelet counts. Patients with a high level of HOTAIR expression had relatively poor overall survival and relapse-free survival times compared with those with a low level of HOTAIR expression. |
| Pubmed ID | 26622861 |
| Year | 2015 |
| Title | Overexpression of long non-coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |