Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute monocytic leukemia |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | bone marrow |
| Expression Pattern | up-regulated |
| Function Description | Expression of HOTAIR in patients with acute monocytic leukemia (M5) was increased as compared to controls. In addition, the expression of downstream genes in the HOTAIR signaling pathway including EZH2, LSD1, DNMT3A and DNMT3B was significantly increased in AL patients, and showed a significant positive correlation with high expression of HOTAIR. |
| Pubmed ID | 27748863 |
| Year | 2016 |
| Title | Role of HOTAIR in the diagnosis and prognosis of acute leukemia. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for acute monocytic leukemia | OMIM COSMIC |