Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | blood |
| Expression Pattern | up-regulated |
| Function Description | The expression level of HOTAIR in OS tissues was significantly higher than that in corresponding normal tissues. Subjects with the rs7958904 CC genotype had significantly lower HOTAIR RNA levels than those with the GG genotypes in normal and OS tissues. |
| Pubmed ID | 26967389 |
| Year | 2016 |
| Title | Genetic variants of lncRNA HOTAIR contribute to the risk of osteosarcoma. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |