Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR etc. |
| Sample | blood |
| Expression Pattern | up-regulated |
| Function Description | Plasma long non-coding HOTAIR as anon-invasive biomarker in GC.Plasma HOTAIR was significantly up-regulated in GC patients compared with controls.HOTAIR may also serve as a competitive endogenous RNA (ceRNA). In GC, it prevents transcriptional suppression of HER2 mRNA through competition for miR-331-3p. |
| Pubmed ID | 29683069 |
| Year | 2018 |
| Title | Plasma long non-coding RNA HOTAIR as a potential biomarker for gastric cancer. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |