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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	gastric cancer
ICD-0-3	C16
Methods	qPCR, Western blot
Sample	GC cell lines AGS, MGC-803, SGC-7901, BGC-823, and a normal gastric epithelium cell line GES-1, GC tissue samples and matched adjacent normal tissues
Expression Pattern	up-regulated
Function Description	Te expression levels of HOTAIR were signifcantly upregulated in GC tissues and cell lines. Increased HOTAIR was associated with tumor diferentiation, lymph node and distant metastasis, and clinical stage. Furthermore, the area under the ROC curve (AUC) was up to 0.8416 (95 % CI=0.7661 to 0.9170, P<0.0001). Te sensitivity and specifcity were 66.67 and 87.04%, respectively. Te correlation between HOTAIR expression and overall survival (OS) was statistically signifcant. Te hazard ratio was 2.681, and 95% CI of ratio was 1.370 to 5.248. In addition, knockdown of HOTAIR can inhibit GC cell growth and afect cell cycle distribution. And knockdown of HOTAIR could enhance the protein levels of P21 and P53.
Pubmed ID	31281667
Year	2019
Title	The Association of HOTAIR with the Diagnosis and Prognosis of Gastric Cancer and Its Effect on the Proliferation of Gastric Cancer Cells

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