Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | NA |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Breast Cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot |
| Sample | MCF-7 cell line, MDA-MB231 cell line |
| Expression Pattern | differential expression |
| Function Description | Our results indicated that some of the lncRNAs having tumor suppressor (GAS5, MEG3, lincRNA-p21) and oncogenic roles (HOTAIR) are regulated by c-MYC. |
| Pubmed ID | 31326549 |
| Year | 2019 |
| Title | MYC-Driven Regulation of Long Non-Coding RNA profiles in Breast Cancer Cells |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for Breast Cancer | OMIM COSMIC |