Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | NA |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy,apoptosis | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | ovarian cancer tissues, human ovarian cancer cell lines SKOV3 and A2780 |
| Expression Pattern | up-regulated |
| Function Description | cisplatin could induce activation of protective autophagy in ovarian cancer. Interfering with HOTAIR increased the cisplatin sensitivity in ovarian cancer through reducing cisplatin-induced autophagy |
| Pubmed ID | 30570864 |
| Year | 2018 |
| Title | Knockdown of long non-coding RNA HOTAIR increases cisplatin sensitivity in ovarian cancer by inhibiting cisplatininduced autophagy |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |