Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | adrenocortical carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, other |
| Sample | Adrenal gland tissues and ACC cell lines (SW-13, H295R) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR expression was remarkably increased in ACC with stage III and IV than that of stage I and II. HOTAIR was an independent prognostic factor for DFS and OS of ACC patients. For in vitro experiments, inhibited proliferation and arrested cell cycle were observed in H295R cells transfected with si-HOTAIR. Opposite results were obtained after SW-13 cells were transfected with HOTAIR overexpression plasmid. Furthermore, expressions of cell cycle-related genes, including Cyclin D1, p-Rb and p-GSK3? were remarkably decreased after HOTAIR knockdown. |
| Pubmed ID | 30402836 |
| Year | 2018 |
| Title | LncRNA HOTAIR participates in the development and progression of adrenocortical carcinoma via regulating cell cycle. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for adrenocortical carcinoma | OMIM COSMIC |