Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | advanced chronic myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, other, other |
| Sample | CML cell lines(KCL22 and K562 cells) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR knockdown and miR-143 overexpression both inhibited proliferation and promoted apoptosis in KCL22 and K562 cells through the PI3K/AKT pathway. RNA pull-down, mass spectrometry, and RIP assays showed that HOTAIR interacted with EZH2 and LSD1. A dual-luciferase assay demonstrated that HOTAIR interacted with miR-143. |
| Pubmed ID | 30464631 |
| Year | 2018 |
| Title | Epigenetic Regulation of HOTAIR in Advanced Chronic Myeloid Leukemia |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for advanced chronic myeloid leukemia | OMIM COSMIC |