Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | NA |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Gefitinib | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | cell lines (95C, 95D, YTMLC-90) |
| Expression Pattern | up-regulated |
| Function Description | we found that almost all lung cancer primary tumors had high expression levels of HOTAIR, while in normal lung cancer tissue, expression levels were lower. We identified that HOTAIR and its 2 segments, HOTAIR3' and HOTAIR5', promote the cell cycle passing through the restriction point during G1-S phase by regulating the Rb-E2F pathway and influence non-small-cell lung cancer cell proliferation, migration and invasion through epithelial-mesenchymal transition (EMT) and the ?-catenin pathway in vitro and vivo. we showed that the high expression of HOTAIR was associated with resistance to gefitinib through the dysregulated cell cycle. |
| Pubmed ID | 30047193 |
| Year | 2018 |
| Title | HOTAIR, a Long Noncoding RNA, Is a Marker of Abnormal Cell Cycle Regulation in Lung Cancer. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |