Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | NA |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Fluorescent in situ hybridization, Western blot |
| Sample | renal cell carcinoma tissues, cell lines (ACHN, 786-O) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR level was confirmed to be significantly upregulated in RCC samples and RCC cell lines compared with those in the paired adjacent tissues and normal renal cell line. Further results indicated that HOTAIR promoted the proliferation and metastasis as a competing endogenous RNA to regulate ST8SIA4 expression by sponging miR-124 in RCC. The survival data based on the expression of HOTAIR in the Cancer Genome Atlas (TCGA) showed that HOTAIR expression level affected the patient survival. HOTAIR mediated cell proliferation, apoptosis, migration and invasion in RCC cell lines. |
| Pubmed ID | 30105850 |
| Year | 2018 |
| Title | Long noncoding RNA HOTAIR promotes renal cell carcinoma malignancy through alpha-2, 8-sialyltransferase 4 by sponging microRNA-124. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |