Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | NA |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP etc. |
| Sample | AML tissues ??uman leukemia cell lines (HL-60, K562, THP-1 and U937) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA HOTAIR was found to be upregulated in AML cells and tissues. With silencing of HOTAIR and overexpression of HOXA5, AML cell proliferation was decreased while the apoptosis was induced.Furthermore, HOTAIR was observed to recruit Dnmt3b and to increase HOXA5 promoter methylation. Moreover, silencing HOTAIR and upregulating HOXA5 were found to induce apoptosis and reduce proliferation of AML cells in vivo. |
| Pubmed ID | 31168296 |
| Year | 2019 |
| Title | Silencing Long Non-Coding RNA HOTAIR Exerts Anti-Oncogenic Effect on Human Acute Myeloid Leukemia via Demethylation of HOXA5 by Inhibiting Dnmt3b |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |