Basic Information
| LncRNA/CircRNA Name | AK096174 |
| Synonyms | NA |
| Region | GRCh38_12:121794810-121797029 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, qPCR, Western blot etc. |
| Sample | gastric cancer tissues, cell lines (GES-1, SGC-7901, MGC-803, MKN-28, AGS and BGC-823) |
| Expression Pattern | up-regulated |
| Function Description | We identified a novel lncRNA, AK096174, which was upregulated and associated with tumorigenesis, tumor size, metastasis, and poor prognosis in gastric cancer. Our data showed that AK096174 was highly expressed in the gastric cancer tissues and cell lines (SGC-7901, AGS, BGC-823, MGC-803), and patients with higher AK096174 expression had a poorer prognosis and shorter overall survival. AK096174 knockdown inhibited the proliferation, migration and invasiveness in SGC-7901 and BGC-823 cells, whereas AK096174 overexpression had the promoting effects. Furthermore, mechanistic investigation showed that AK096174 positively correlated with the expression of WD repeat-containing protein 66 (WDR66) gene at the translational level. Knockdown of WRD66 attenuated the positive impact of AK096174 in gastric cancer cells. |
| Pubmed ID | 29717028 |
| Year | 2018 |
| Title | Long non-coding RNA AK096174 promotes cell proliferation and invasion in gastric cancer by regulating WDR66 expression. |
External Links
| Links for AK096174 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |