Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | NA |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | RT-PCR , Northern blot etc. |
| Sample | NSCLC tissues and adjacent normal tissues ,NSCLC cell lines (A549, H322 and H1299), normal lung cell line (BEAS-2B) |
| Expression Pattern | up-regulated |
| Function Description | The expression of HOTAIR in tissues of clinical patients only exhibited a correlation with the stage of cancer. The expressions of HOTAIR in patients with stage I and II were remarkably lower than those with stage III and IV. Additionally, the expression of HOTAIR was negatively correlated with the expression of miR-221.Further studies revealed that there was a negatively regulatory interaction between miR-221 expression and HOTAIR expression.miR-221 significantly promoted the apoptosis of NSCLC cells by negatively regulating HOTAIR expression. |
| Pubmed ID | 31173294 |
| Year | 2019 |
| Title | Effects of miR-221 on the Apoptosis of Non-Small Cell Lung Cancer Cells by lncRNA HOTAIR |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |