Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOX antisense intergenic RNA |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Trastuzumab | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RT-PCR, Western blot analysis |
| Sample | SK-BR-3 cell line |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR is up-regulated in trastuzumab-resistant cell line SK-BR-3-TR and blocking of HOTAIR expression restores the sensitivity. HOTAIR is involved in acquired resistance via epigenetic modification of methylation in PTEN, demethylation of TGF- ? and cross talk effects from up-and down-regulation of TGF- ? and PTEN that enhance the HER2 phosphorylation -independent activity of the MEK/MAPK pathway to promote the proliferation and invasion of tumor cells. In addition, HOTAIR also regulates the expression of P27, CylinD1 and CDK4 to promote the transition of tumor cells from G1 phase to S phase to inhibit the apoptosis through non-epigenetic mechanism or other indirect regulatory mechanisms. |
| Pubmed ID | 31882666 |
| Year | 2019 |
| Title | Down-regulation of Long Non-Coding RNA HOTAIR Sensitizes Breast Cancer to Trastuzumab |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |