Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | NA |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | RNA-seq, qPCR, Western blot, in vitro knockdown |
| Sample | prostate cancer tissues, cell lines (LNCaP,LNCaP-TR, CWR22Rv1, CWR22Rv1-TR and PC3) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR as a novel REST-repressed lncRNA that is upregulated in NED PCa cells and in CRPC. HOTAIR overexpression is sufficient to induce, whereas knockdown of HOTAIR suppressed NED of PCa cells. |
| Pubmed ID | 29944905 |
| Year | 2018 |
| Title | HOTAIR Is a REST-regulated lncRNA That Promotes Neuroendocrine Differentiation in Castration Resistant Prostate Cancer |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |