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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating	2
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	triple negative breast cancer
ICD-0-3	C50
Methods	qPCR, Western blot, Luciferase reporter assay, etc.
Sample	primary TNBC tumor tissues, The MDA-MB-231 and MDA-MB-468 human TNBC cell lines, and the MCF10A normal human mammary epithelial cell line
Expression Pattern	up-regulated
Function Description	The results revealed increased expression levels of HOST2 in tumor tissues from patients with TNBC. A positive correlation was identified between the expression of HOST2 and cyclin-dependent kinase 6 (CDK6) in tumor tissues. The silencing of HOST2 induced cell proliferation inhibition and cell cycle redistribution in MDA MB 231 and MDA MB 468 TNBC cells. In these two cell lines, HOST2 silencing caused a decrease in the phosphorylation of RB1 and CDK6, which was observed at the mRNA and protein levels. However, the silencing of CDK6 did not alter the expression of HOST2. It was hypothesized and confirmed that let 7b, a previously reported target miRNA of HOST2, was able to directly bind to the 3'UTR of CDK6 and repress its expression. The expression of let 7b was negatively correlated with the expression of HOST2 and CDK6 in tumor tissues.
Pubmed ID	30483747
Year	2018
Title	Knockdown of long non-coding RNA HOST2 inhibits the proliferation of triple negative breast cancer via regulation of the let-7b/CDK6 axis

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