Basic Information
| LncRNA/CircRNA Name | HOST2 |
| Synonyms | CERNA2, HOST2, lncRNA-HOST2 |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_134505 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | sinomenine hydrochloride | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | RT-qPCR, Western blot analyses |
| Sample | ovarian cancer tissues,ovarian epithelial cell line (HOEpiC) and 5 ovarian cancer cell lines (A2780, Caov3, Hey, OVCAR3, and SKOV3) |
| Expression Pattern | up-regulated |
| Function Description | Overexpression of HOST2 significantly reversed the effects of SH on Caov3 cell viability, cell cycle and apoptosis. Clinical findings confirmed that HOST2 was profoundly higher expressed in ovarian cancer tissues and cells, and HOST2 predicated unfavourable prognosis of ovarian cancer individuals. |
| Pubmed ID | 31701766 |
| Year | 2019 |
| Title | Sinomenine Hydrochloride Exerts Antitumor Outcome in Ovarian Cancer Cells by Inhibition of Long Non-Coding RNA HOST2 Expression |
External Links
| Links for HOST2 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |