Basic Information
| LncRNA/CircRNA Name | HOST2 |
| Synonyms | CERNA2, HOST2, lncRNA-HOST2 |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_134505 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc. |
| Sample | TNBC patients cancer tissues and their adjacent noncancerous tissues,cell lines( MDA-MB-231, MDA-MB-468, HCC1937, MCF-7 and SKBR3) |
| Expression Pattern | up-regulated |
| Function Description | The results showed that HOST2 was up-regulated in BC tissues and cell lines. Clinical outcome analysis demonstrated that high expression of HOST2 was associated with poor prognosis of TNBC patients. Functional experiments illustrated that knockdown of HOST2 significantly suppressed TNBC cell proliferation and migration. Western blot assays, qRT-PCR assays, RIP assays and luciferase reporter assays revealed that HOST2 regulated STAT3 via crosstalk with let-7b. |
| Pubmed ID | 32248842 |
| Year | 2020 |
| Title | Long Noncoding RNA HOST2, Working as a Competitive Endogenous RNA, Promotes STAT3-mediated Cell Proliferation and Migration via Decoying of let-7b in Triple-Negative Breast Cancer |
External Links
| Links for HOST2 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |