Basic Information
| LncRNA/CircRNA Name | HNRNPU |
| Synonyms | |
| Region | GRCh38_1:244840638-244864560 |
| Ensemble | ENSG00000153187 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic ductal adenocarcinoma |
| ICD-0-3 | C25.3 |
| Methods | qPCR, Microarray |
| Sample | Human pancreatic cancer cell lines (Panc1, MiaPaCa-2, BxPC3, PL45).Pancreatic ductal adenocarcinoma. |
| Expression Pattern | up-regulated |
| Function Description | We used a custom cDNA microarray platform to profile the expression of 22,875 lncRNAs. A number of lncRNAs were differentially expressed in patients' specimens. We focused our attention on one lncRNA transcript in particular, heterogeneous nuclear ribonucleoprotein U (HNRNPU, also known as ncRNA00201) processed transcript, as it was one of the most highly deregulated lncRNAs in PDAC. Knockdown of HNRNPU processed transcript reduces proliferation and in vitro migration/invasion of PDAC cell lines.We also mined the most recent version of the TCGA metadata for PDAC to determine if HNRNPU processed transcript correlated with patient survival, however the result was not statistically significant. |
| Pubmed ID | 29657295 |
| Year | 2017 |
| Title | Expression Profiling Identifies the Noncoding Processed Transcript of HNRNPU with Proliferative Properties in Pancreatic Ductal Adenocarcinoma. |
External Links
| Links for HNRNPU | GenBank HGNC NONCODE |
| Links for pancreatic ductal adenocarcinoma | OMIM COSMIC |