Basic Information
| LncRNA/CircRNA Name | HNF1A-AS1 |
| Synonyms | HNF1A-AS1, C12orf27, NCRNA00262 |
| Region | GRCh38_12:120941728-120980965 |
| Ensemble | ENSG00000241388 |
| Refseq | NR_024345 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Luciferase reporter assay |
| Sample | NSCLC tissues, NSCLC cell lines (H1299, H1650, A549, and PC9) |
| Expression Pattern | up-regulated |
| Function Description | HNF1A-AS1 was upregulation in NSCLC tissues and cell lines.High HNF1A-AS1 expression was associated with patients' advanced TNM stage and lymph node metastasis.Reduced HNF1A-AS1 expression inhibited lung cancer cells proliferation, invasion and increased cells apoptosis rate. Bioinformatics analysis and luciferase reporter assay revealed that HNF1A-AS1 interacted with miR-17-5p by directly targeting it. Rescue experiments showed that miR-17-5p suppression reversed the tumor-suppressing role of HNF1A-AS1 knockdown on NSCLC progression. |
| Pubmed ID | 29289833 |
| Year | 2017 |
| Title | Long non-coding RNA HNF1A-AS1 promotes cell proliferation and invasion via regulating miR-17-5p in non-small cell lung cancer. |
External Links
| Links for HNF1A-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |