Basic Information
| LncRNA/CircRNA Name | HNF1A-AS1 |
| Synonyms | HNF1A-AS1, C12orf27, NCRNA00262 |
| Region | GRCh38_12:120941728-120980965 |
| Ensemble | ENSG00000241388 |
| Refseq | NR_024345 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR etc. |
| Sample | cell lines (SW480, SW620, DLD1, HT29, HCT116, Ls174T, LOVO) |
| Expression Pattern | up-regulated |
| Function Description | The results demonstrated that HNF1A-AS1 was distinctly upregulated in CRC tissues and associated with CRC metastasis to the lymph nodes. Reverse transcription quantitative polymerase chain reaction revealed that HNF1A-AS1 was also upregulated in CRC cell lines and localized in the nucleus. In addition, knockdown of HNF1A-AS1 expression notably inhibited CRC cell proliferation, migration, invasion and colony formation, and suppressed Sphase entry in vitro. Taken together, these results suggested that HNF1A-AS1 might serve as a promising prognostic marker for CRC tumorigenesis and progression. |
| Pubmed ID | 28791380 |
| Year | 2017 |
| Title | Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma |
External Links
| Links for HNF1A-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |