Basic Information
| LncRNA/CircRNA Name | HNF1A-AS1 |
| Synonyms | NA |
| Region | GRCh38_12:120941728-120980965 |
| Ensemble | ENSG00000241388 |
| Refseq | NR_024345 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Dual luciferase reporter assays, ChIP, RIP |
| Sample | gastric cancer tissues, cell lines (MKN-45, BGC-823, HEK293) |
| Expression Pattern | up-regulated |
| Function Description | we demonstrate that the expression of hepatocyte nuclear factor 1 homeobox A antisense RNA 1 (HNF1A-AS1) is significantly upregulated in gastric cancer tissues. Overexpression of HNF1A-AS1 enhanced cell proliferation and promoted cell-cycle progression. HNF1A-AS1 functioned as competing endogenous RNA (ceRNA) by binding to miR-661 |
| Pubmed ID | 30185552 |
| Year | 2018 |
| Title | EGR1-Mediated Transcription of lncRNA-HNF1A-AS1 Promotes Cell-Cycle Progression in Gastric Cancer. |
External Links
| Links for HNF1A-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |