Basic Information
| LncRNA/CircRNA Name | HNF1A-AS1 |
| Synonyms | HNF1A antisense RNA 1 |
| Region | GRCh38_12:120941728-120980965 |
| Ensemble | ENSG00000241388 |
| Refseq | NR_024345 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | Dual luciferase reporter gene assay, RIP, RT-qPCR, Western blot assay |
| Sample | cervical epithelial cells HcerEpic, DDP-sensitive CC cell line HeLa/S and DDP-resistant cell line HeLa/DDP |
| Expression Pattern | up-regulated |
| Function Description | HNF1A-AS1 was upregulated in DDP-resistant cell line HeLa/DDP. Silencing HNF1A-AS1 suppressed CC cell proliferation and promoted its apoptosis. HNF1A-AS1 was found to act as a competing endogenous RNA (ceRNA) of miR-34b to promote the expression of TUFT1. Exosomes shuttled HNF1A-AS1 promoted the proliferation and drug resistance of CC cells and inhibited their apoptosis by upregulating the expression of TUFT1 and downregulating miR-34b. Furthermore, suppressed exosomal HNF1A-AS1 in combination with DDP inhibited tumor growth in nude mice. |
| Pubmed ID | 31827397 |
| Year | 2019 |
| Title | Exosomal lncRNA HNF1A-AS1 Affects Cisplatin Resistance in Cervical Cancer Cells Through Regulating microRNA-34b/TUFT1 Axis |
External Links
| Links for HNF1A-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |