Basic Information
| LncRNA/CircRNA Name | HNF1A-AS1 |
| Synonyms | NA |
| Region | GRCh38_12:120941728-120980965 |
| Ensemble | ENSG00000241388 |
| Refseq | NR_024345 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc. |
| Sample | colon cancer and adjacent normal tissues, cell lines (LoVo , SW620 , HCT 116,SW480 ,FHC,HUVEC) |
| Expression Pattern | up-regulated |
| Function Description | HNF1A-AS1 and OTX1 were highly expressed in colon cancer.Silencing of HNF1A-AS1 inhibited angiogenesis of colon cancer in vivo and in vitro. HNF1A-AS1 increased the OTX1 expression by binding to transcription factor PBX3 to promote angiogenesis in colon cancer. |
| Pubmed ID | 32325080 |
| Year | 2020 |
| Title | Long non-coding RNA HNF1A-AS1 upregulates OTX1 to enhance angiogenesis in colon cancer via the binding of transcription factor PBX3. |
External Links
| Links for HNF1A-AS1 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |