Basic Information
| LncRNA/CircRNA Name | HNF1A-AS |
| Synonyms | HNF1A-AS1, C12orf27, NCRNA00262 |
| Region | GRCh38_12:120941728-120980965 |
| Ensemble | ENSG00000241388 |
| Refseq | NR_024345 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, RNAi, Cell proliferation assay etc. |
| Sample | NPC tissues, cell lines (5-8F, 6-10B, HONE-1, CNE-2, SUNE-1, C666-1, and NP69) |
| Expression Pattern | up-regulated |
| Function Description | Compared with matched, non-cancerous tissues, clinical NPC tissues from 20 patients showed higher expression of HNF1A-AS on average. Lentivirus-mediated HNF1A-AS knockdown suppressed cell proliferation and migration abilities. In mice injected with CNE-2 and SUNE-1, depletion of HNF1A-AS caused inhibition of tumor growth, whereas cell cycle analysis showed that HNF1A-AS-knockdown resulted in cell accumulation in the G0/G1 phase. Moreover, HNF1A-AS was found to be associated with epithelial to mesenchymal transition. |
| Pubmed ID | 26756620 |
| Year | 2016 |
| Title | Long non-coding RNA HNF1A-AS is upregulated and promotes cell proliferation and metastasis in nasopharyngeal carcinoma. |
External Links
| Links for HNF1A-AS | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |