Basic Information
| LncRNA/CircRNA Name | Hmrhl |
| Synonyms | human Mrhl |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | conservation | Recurrence |
Cancer&Entry Information
| Cancer Name | chronic myelogenous leukemia |
| ICD-0-3 | NA |
| Methods | luciferase assay, RT-qPCR |
| Sample | K562 (Chronic Myelogenous Leukemia/Erythro Leukemia) cell line,Hek293T cells,GM12878 cell line |
| Expression Pattern | up-regulated |
| Function Description | it is highly upregulated in leukemia as well as several cases of lymphoma.siRNA mediated down-regulation of Hmrhl in K562 cells leads to a concomitant down regulation of its parent gene, phkb, showing that Hmrhl functions as an enhancer RNA and positively regulates its host gene, phkb, in chronic myelogenous leukemia.the enhancer properties of Hmrhl locus in K562 cells. |
| Pubmed ID | 31891018 |
| Year | 2019 |
| Title | A Novel Enhancer RNA, Hmrhl, Positively Regulates Its Host Gene, phkb, in Chronic Myelogenous Leukemia |
External Links
| Links for Hmrhl | GenBank HGNC NONCODE |
| Links for chronic myelogenous leukemia | OMIM COSMIC |