Basic Information
| LncRNA/CircRNA Name | HMMR-AS1 |
| Synonyms | NA |
| Region | GRCh38_5:163483065-163494058 |
| Ensemble | ENSG00000251018 |
| Refseq | NR_109892 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | LUAD and adjacent non-tumor tissues ,LUAD cell lines (A549, NCI-H23, PC-9, C422L, and HCC827) ,human normal bronchi epithelium (HBE) cell line |
| Expression Pattern | up-regulated |
| Function Description | HMMR-AS1 expression was significantly upregulated in LUAD tissues and was associated with larger tumor diameter, advanced TNM stage, lymph node metastasis, and shorter survival.Knockdown of HMMR-AS1 induced apoptosis and growth arrest in vitro and inhibited tumorigenesis in mouse xenografts.HMMR-AS1 functioned as a ceRNA of miR-138, thereby leading to repression of its endogenous target sirt6. Moreover, knockdown of HMMR-AS1 dramatically inhibited tumor growth and metastasis of LUAD in vivo. |
| Pubmed ID | 31128573 |
| Year | 2019 |
| Title | LncRNA HMMR-AS1 Promotes Proliferation and Metastasis of Lung Adenocarcinoma by Regulating MiR-138/sirt6 Axis |
External Links
| Links for HMMR-AS1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |