Basic Information
| LncRNA/CircRNA Name | HIT000218960 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | PTC tissues, cell lines (TPC1 and BCPAP) |
| Expression Pattern | up-regulated |
| Function Description | We observed that a newly identified lncRNA, HIT000218960, was significantly upregulated in PTC tissues. In addition, functional assays indicated that inhibition of HIT000218960 in PTC cells suppressed cell proliferation, colony formation, migration and invasion in vitro. Increased HIT000218960 expression in PTC tissues was obviously correlated with lymph node metastasis and multifocality, as well as TNM stage. |
| Pubmed ID | 27929737 |
| Year | 2017 |
| Title | Long noncoding RNA HIT000218960 promotes papillary thyroid cancer oncogenesis and tumor progression by upregulating the expression of high mobility group AT-hook 2 (HMGA2) gene. |
External Links
| Links for HIT000218960 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |