Basic Information
| LncRNA/CircRNA Name | HIPK1-AS |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Sipi soup | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | Microarray, qPCR, in vitro knockdown |
| Sample | cervical cancer tissues, cell lines (HeLa) |
| Expression Pattern | up-regulated |
| Function Description | Analysis with a long non-coding (lnc)RNA array of numerous differentially expressed lncRNAs revealed that the expression levels of the lncRNA homeodomain-interacting protein kinase 1 antisense RNA (HIPK1-AS) were increased in cervicitis tissues and cervical squamous cell carcinoma tissues compared with in normal cervical tissues. HIPK1-AS expression levels were upregulated in response to HeLa CM, but were decreased under Sipi soup treatment. The downregulation of HIPK1-AS expression via short hairpin RNA abolished the effects of HeLa CM on the expression of inflammation-associated genes. |
| Pubmed ID | 29901171 |
| Year | 2018 |
| Title | Sipi Soup Inhibits Cancer-associated Fibroblast Activation and the Inflammatory Process by Downregulating Long Non-coding RNA HIPK1-AS |
External Links
| Links for HIPK1-AS | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |