Basic Information
| LncRNA/CircRNA Name | HIF2PUT |
| Synonyms | EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73 |
| Region | GRCh38_2:46293667-46386703 |
| Ensemble | ENSG00000116016 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi etc. |
| Sample | osteosarcoma tissues, cell lines (SAOS2, MG63, U2OS) |
| Expression Pattern | differential expression |
| Function Description | HIF2PUT expression levels were positively correlated with HIF-2a in osteosarcoma tissues. Overexpression of HIF2PUT markedly inhibited cell proliferation and migration, decreased the percentage of CD133 expressing cells, and impaired the osteosarcoma stem sphere-forming ability of the MG63 cells. Furthermore, altering the expression of HIF2PUT resulted in a concomitant change to HIF-2a mRNA expression. |
| Pubmed ID | 25434862 |
| Year | 2014 |
| Title | A novel long non-coding RNA, hypoxia-inducible factor-2a promoter upstream transcript, functions as an inhibitor of osteosarcoma stem cells in vitro. |
External Links
| Links for HIF2PUT | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |