Basic Information
| LncRNA/CircRNA Name | HIF2PUT |
| Synonyms | EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73 |
| Region | GRCh38_2:46293667-46386703 |
| Ensemble | ENSG00000116016 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR etc. |
| Sample | osteosarcoma tissues |
| Expression Pattern | up-regulated |
| Function Description | Compared with non-cancerous bone tissues, HIF-2a mRNA and HIF2PUT expression were both significantly upregulated in osteosarcoma tissues. Interestingly, the expression levels of HIF-2a mRNA in osteosarcoma tissues were positively correlated with those of HIF2PUT. Additionally, osteosarcoma patients with HIF-2a mRNA and/or HIF2PUT over-expression more frequently had large tumor size, advanced clinical stage and positive distant metastasis. Moreover, osteosarcoma patients with HIF-2a mRNA and/or HIF2PUT over-expression had a significantly shorter overall and disease-free survival. |
| Pubmed ID | 27623205 |
| Year | 2016 |
| Title | Combined over-expression of the hypoxia-inducible factor 2a gene and its long non-coding RNA predicts unfavorable prognosis of patients with osteosarcoma. |
External Links
| Links for HIF2PUT | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |