Basic Information
| LncRNA/CircRNA Name | HIF1A-AS2 |
| Synonyms | NA |
| Region | GRCh38_14:61715558-61751097 |
| Ensemble | ENSG00000258667 |
| Refseq | NR_045406 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, etc. |
| Sample | TNBC tissues, non-TNBC tissues, MCF-10A, DU4475, HCC1806, and MDAMB468 |
| Expression Pattern | up-regulated |
| Function Description | HIF1A AS2 was also found to be upregulated in TNBC tissues compared with non TNBC tissues or adjacent normal tissues. Besides, HIF1A AS2 expression was also elevated in TNBC cell lines compared with the normal breast epithelial cell line. Moreover, high expression of HIF1A AS2 was associated with lymph node metastasis, distant metastasis and unfavorable histological grade in TNBC patients. Survival analysis showed a TNBC patient with high HIF1A AS2 expression had shorter overall survival than patients with low HIF1A AS2 expression, and HIF1A AS2 high expression acted as an independent poor prognostic factor for overall survival in TNBC patients. The cell migration and invasion assays suggested inhibition of HIF1A AS2 obviously depressed TNBC cell migration and invasion. |
| Pubmed ID | 30635931 |
| Year | 2019 |
| Title | HIF1A-AS2 predicts poor prognosis and regulates cell migration and invasion in triple-negative breast cancer. |
External Links
| Links for HIF1A-AS2 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |