Basic Information
| LncRNA/CircRNA Name | lncRNA-HEIH |
| Synonyms | HEIH, HCCAT2, LINC-HEIH, LINC00848, lncRNA-HEIH |
| Region | GRCh38_5:180829954-180831605 |
| Ensemble | ENSG00000278970 |
| Refseq | NR_045680 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, other |
| Sample | NSCLC tissues and cell lines (A549, H125, H299, and Calu) |
| Expression Pattern | up-regulated |
| Function Description | In our study, we confirmed the elevated expression of HEIH in NSCLC tissues and cell lines compared with the normal ones. After constructing A549 and Calu-1 cells with altered HEIH expression by transient transfection, cell viability was found to be positively regulated by the HEIH level. Moreover, overexpression of HEIH accelerated the cell migrating rate and increased the invasive cell number according to the results of a wound healing assay and transwell assay. |
| Pubmed ID | 30230600 |
| Year | 2019 |
| Title | Long Noncoding RNA HEIH Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer |
External Links
| Links for lncRNA-HEIH | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |