Basic Information
| LncRNA/CircRNA Name | HCP5 |
| Synonyms | NA |
| Region | GRCh38_6:31400702-31477506 |
| Ensemble | ENSG00000206337 |
| Refseq | NR_040662 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | Human embryonic permanent osteogenic cell line (hFOB1.19) and human osteosarcoma cell lines, including SaOS2, U2OS, MG-63 and HOS, |
| Expression Pattern | up-regulated |
| Function Description | Northern blot assay further proved the higher expression of HCP5 in OS cell lines.?To identify the biological role of HCP5 in OS, we silenced the expression of HCP5 in U2OS and MG-63 cells which possessed the highest level of HCP5.?CCK-8 and colony formation assay revealed the inhibitory effect of HCP5 knockdown on cell proliferation.?Cell apoptosis was found to be increased in cells transfected with sh-HCP5.?Moreover, cell invasion and epithelial-mesenchymal transition (EMT) were reversed by the silencing of HCP5.?The results of functional assays showed that HCP5 acted as an oncogene in osteosarcoma.Mechanically, HCP5 was found to be activated by the transcription factor SP1.?Finally, rescue assays were conducted to demonstrate the function of SP1/HCP5 axis in osteosarcoma. |
| Pubmed ID | 30554864 |
| Year | 2019 |
| Title | SP1-induced Upregulation of Long Non-Coding RNA HCP5 Promotes the Development of Osteosarcoma |
External Links
| Links for HCP5 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |