Basic Information
| LncRNA/CircRNA Name | HCP5 |
| Synonyms | NA |
| Region | GRCh38_6:31400702-31477506 |
| Ensemble | ENSG00000206337 |
| Refseq | NR_040662 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, in vitro knockdown, Western blot analysis, Chromatin immunoprecipitation etc. |
| Sample | human lung adenocarcinoma cell lines (A549, PC9, H1975, Calu3) and the normal human bronchial epithelial cell line (HBE) |
| Expression Pattern | up-regulated |
| Function Description | HCP5 is induced by TGF? and transcriptionally regulated by SMAD3, which promotes LUAD tumor growth and metastasis. Moreover, HCP5 is overexpressed in tumor tissues of patients with LUAD, specifically in patients with EGFR and KRAS mutations and current smoker. HCP5 high expression level is positively correlated with poor prognosis of patients with LUAD. Finally, upregulation of HCP5 increases the expression of Snail and Slug by sponging the microRNA-203 (miR-203) and promoting epithelial-mesenchymal transition (EMT) in LUAD cells. |
| Pubmed ID | 31131047 |
| Year | 2019 |
| Title | HCP5 Is a SMAD3-responsive Long Non-Coding RNA That Promotes Lung Adenocarcinoma Metastasis via miR-203/SNAI Axis |
External Links
| Links for HCP5 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |