Basic Information
| LncRNA/CircRNA Name | HCN3 |
| Synonyms | HCN3 |
| Region | GRCh38_1:155277583-155289848 |
| Ensemble | ENSG00000143630 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | neuroblastoma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, Western blot, Cell proliferation assay, in vitro knockdown etc. |
| Sample | neuroblastoma tissues |
| Expression Pattern | up-regulated |
| Function Description | HCN3 and linc01105 exhibited the higher expression in neuroblastoma tissue, whereas MEG3 displayed the lower expression. Moreover, linc01105 knockdown promoted cell proliferation, whereas MEG3 overexpression inhibited proliferation. Finally, linc01105 knockdown, MEG3 overexpression and HCN3 knockdown all increased apoptosis. |
| Pubmed ID | 27824082 |
| Year | 2016 |
| Title | MEG3, HCN3 and linc01105 influence the proliferation and apoptosis of neuroblastoma cells via the HIF-1a and p53 pathways. |
External Links
| Links for HCN3 | GenBank HGNC NONCODE |
| Links for neuroblastoma | OMIM COSMIC |