Basic Information
| LncRNA/CircRNA Name | AK055347 |
| Synonyms | FAM78B |
| Region | GRCh38_1:166057426-166166969 |
| Ensemble | ENSG00000188859 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | osteosarcoma tissues, cell lines (SOSP-9607, MG63 and F5M2) |
| Expression Pattern | differential expression |
| Function Description | Notably, downregulation of Oct4 decreased the expression of AK055347, a newly identified long noncoding RNA (lncRNA) in human tissues. The downregulation of AK055347 by siRNA resulted in a significant suppressive effect on proliferative and invasive ability, and promotion of cell apoptosis in osteosarcoma cells. |
| Pubmed ID | 28123573 |
| Year | 2017 |
| Title | Transcription factor Oct4 promotes osteosarcoma by regulating lncRNA AK055347. |
External Links
| Links for AK055347 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |