Basic Information
| LncRNA/CircRNA Name | HCG11 |
| Synonyms | NA |
| Region | GRCh38_6:26521709-26527404 |
| Ensemble | ENSG00000228223 |
| Refseq | NR_026790 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | glioma specimens and the non-tumorous tissues |
| Expression Pattern | down-regulated |
| Function Description | HCG11 was expressed at low level in glioma samples compared with normal samples. FOXP1 could bind with HCG11 and transcriptionally inactivated HCG11. Overexpression of HCG11 efficiently suppressed cell proliferation, induced cell cycle arrest and promoted cell apoptosis. HCG11 was predominantly enriched in the cytoplasm of glioma cells and acted as a competing endogenous RNAs (ceRNAs) by sponging micro-496 to upregulate cytoplasmic polyadenylation element binding pro- tein 3 (CPEB3). CEPB3 and miR-496 involved in HCG11-mediated glioma progression |
| Pubmed ID | 31310044 |
| Year | 2019 |
| Title | Long non-coding RNA HCG11 modulates glioma progression through cooperating with miR-496/CPEB3 axis |
External Links
| Links for HCG11 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |