Basic Information
| LncRNA/CircRNA Name | HCG11 |
| Synonyms | HLA complex group 11 |
| Region | GRCh38_6:26521709-26527404 |
| Ensemble | ENSG00000228223 |
| Refseq | NR_026790 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Western blot Assay, Dual Luciferase Reporter Assay |
| Sample | HCC tissues,HCC cell lines MHCC97-H, Hep3B, and normal liver cell line THLE-2 |
| Expression Pattern | up-regulated |
| Function Description | The enrichment of HCG11 was enhanced in HCC tissues and cells and was negatively related to the prognosis of HCC patients. The abundance of miR-26a-5p was inversely correlated with the level of HCG11 in HCC tissues. HCG11 interference suppressed the proliferation, metastasis, and autophagy while promoted the apoptosis of HCC cells.HCG11 promoted the growth of murine xenograft tumor and autophagy through miR-26a-5p/ATG12 axis in vivo. |
| Pubmed ID | 31858580 |
| Year | 2019 |
| Title | LncRNA HCG11 Accelerates the Progression of Hepatocellular Carcinoma via miR-26a-5p/ATG12 Axis |
External Links
| Links for HCG11 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |