Basic Information
| LncRNA/CircRNA Name | HCG11 |
| Synonyms | NA |
| Region | GRCh38_6:26521709-26527404 |
| Ensemble | ENSG00000228223 |
| Refseq | NR_026790 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blot, RIP, Luciferase reporter assay |
| Sample | GC tissues,gastric cell (SNU-1) and gastric cancer cells (AGS, BGC-823, SGC-7901, SWMGC-803480) |
| Expression Pattern | up-regulated |
| Function Description | HCG11 was discovered highly expressed in GC tissues and cells. Depletion experiments were used to evaluate HCG11 silence on cell proliferation, migration and apoptosis. Moreover, Wnt signaling pathway was found as a tumor promoter in GC.HCG11 accelerated proliferation and migration in GC through miR-1276/CTNNB1 and Wnt signaling pathway. |
| Pubmed ID | 31889902 |
| Year | 2019 |
| Title | LncRNA HCG11 Promotes Proliferation and Migration in Gastric Cancer via Targeting miR-1276/CTNNB1 and Activating Wnt Signaling Pathway |
External Links
| Links for HCG11 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |