Basic Information
| LncRNA/CircRNA Name | HCG11 |
| Synonyms | NA |
| Region | GRCh38_6:26521709-26527404 |
| Ensemble | ENSG00000228223 |
| Refseq | NR_026790 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal cancer |
| ICD-0-3 | C32 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc |
| Sample | laryngeal carcinoma tissues, cell lines (SNU46, SNU899, AMC-HN-8, NP69) |
| Expression Pattern | down-regulated |
| Function Description | Low expression of HCG11 was discovered in laryngeal carcinoma tissues and cells. Overexpression of HCG11 retarded cell proliferation and enhanced cell apoptosis. Later, we found that APOM was also downregulated in laryngeal carcinoma tissues and cell lines, and inhibited laryngeal carcinoma progression. HCG11 positively regulated APOM at the post-transcriptional level. MiR-4469 was predicted to have the binding sites of HCG11 and APOM. |
| Pubmed ID | 32271435 |
| Year | 2020 |
| Title | LncRNA HCG11 Suppresses Laryngeal Carcinoma Cells Progression via Sponging miR-4469/APOM Axis |
External Links
| Links for HCG11 | GenBank HGNC NONCODE |
| Links for laryngeal cancer | OMIM COSMIC |