Basic Information
| LncRNA/CircRNA Name | HAS2-AS1 |
| Synonyms | NA |
| Region | GRCh38_8:121639293-121644693 |
| Ensemble | ENSG00000248690 |
| Refseq | NR_002835 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | RT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | epithelial ovarian cancer tissue and corresponding adjacent noncancerous tissues ,Epithelial ovarian cancer cell lines (SKOV3, OV420, A2780 and HO8910) ,normal human ovarian epithelial cell line (HOSEPiC) |
| Expression Pattern | up-regulated |
| Function Description | In the cells and tissue of EOC, HAS2-AS1 expression was markedly up-regulated. Besides, the overexpression of HAS2-AS1 indicated the poor clinical outcome of EOC patients.Transcription factor CREB1 could bind with the promoter of HAS2-AS1 and activate its transcriptional expression.HAS2-AS1 knockdown suppressed the proliferation, invasion and tumor growth of EOC cells in vitro and in vivo.HAS2-AS1 could relive the RUNX2 protein expression via sponging the miR-466, acting as miRNA sponge. |
| Pubmed ID | 31082772 |
| Year | 2019 |
| Title | CREB1 Induced lncRNA HAS2-AS1 Promotes Epithelial Ovarian Cancer Proliferation and Invasion via the miR-466/RUNX2 Axis |
External Links
| Links for HAS2-AS1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |