Basic Information
| LncRNA/CircRNA Name | HAND2-AS1 |
| Synonyms | HAND2-AS1, DEIN, NBLA00301, UPH |
| Region | GRCh38_4:173527270-173659696 |
| Ensemble | ENSG00000237125 |
| Refseq | NR_136192 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrioid endometrial cancer |
| ICD-0-3 | NA |
| Methods | RNA-seq, qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | EEC tissue, endometrial cancer cell lines (HEC1-A, HEC1-B, AN3CA, KLE, RL95-2) |
| Expression Pattern | down-regulated |
| Function Description | HAND2-AS1 and HAND2 were frequently down-regulated in EEC tissues, especially in poor differentiated tumor tissues. Down-regulation of HAND2-AS1 and HAND2 was correlated with tumor grade, lymph node metastasis and recurrence of EEC patients. HAND2-AS1 and HAND2 were co-downregulated by promoter DNA hypermethylation in EEC.overexpression of HAND2 also inhibited migration and invasion EEC cells indicating that HAND2-AS1 and HAND2 had a concordant role in the progression of EEC. However, HAND2 was not regulated by HAND2-AS1 in EEC. Furthermore, the anti-tumorigenic effect of HAND2-AS1 was mediated by down-regulating NMU, which has an oncogenic role in EEC. |
| Pubmed ID | 29107108 |
| Year | 2017 |
| Title | Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U. |
External Links
| Links for HAND2-AS1 | GenBank HGNC NONCODE |
| Links for endometrioid endometrial cancer | OMIM COSMIC |