Basic Information
| LncRNA/CircRNA Name | HAND2-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:173527270-173659696 |
| Ensemble | ENSG00000237125 |
| Refseq | NR_136192 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Conservation | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qPCR, Western blot, RIP |
| Sample | Human hepatocellular carcinoma (HCC) cell lines Hep3B, Huh7, and PLC/PRF/5, liver tumor and paired peri-tumor tissues |
| Expression Pattern | up-regulated |
| Function Description | HAND2-AS1 that is highly expressed in liver CSCs. Human HAND2-AS1 and its mouse ortholog lncHand2 display a high level of conservation. HAND2-AS1 is required for the selfrenewal maintenance of liver CSCs to initiate HCC development. Mechanistically, HAND2-AS1 recruits the INO80 chromatin-remodeling complex to the promoter of BMPR1A, thereby inducing its expression and leading to the activation of BMP signaling. Importantly, interfering with expression of HAND2-AS1 by antisense oligonucleotides (ASOs) and BMPR1A by siRNAs has synergistic antitumorigenic effects on humanized HCC models. Moreover, knockout of lncHand2 or Bmpr1a in mouse hepatocytes impairs BMP signaling and suppresses the initiation of liver cancer. |
| Pubmed ID | 31334575 |
| Year | 2019 |
| Title | LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling |
External Links
| Links for HAND2-AS1 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |