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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	esophagus squamous cell carcinoma
ICD-0-3	NA
Methods	qPCR, etc.
Sample	ESCC tissue, ESCC cell lines KYSE-30 and KYSE70
Expression Pattern	down-regulated
Function Description	lncRNA HAND2 AS1 was downregulated, while microRNA 21 (miRNA 21) was upregulated in tumor tissues than in adjacent healthy tissues of ESCC patients. Expression levels of lncRNA HAND2 AS1 and miRNA 21 were significantly and inversely correlated in tumor tissues but not in healthy tissues. Plasma levels of lncRNA HAND2 AS1 were lower in ESCC patients than in healthy controls, and downregulation of plasma lncRNA HAND2 AS1 distinguished early stage ESCC patients from healthy controls. lncRNA HAND2 AS1 overexpression resulted in downregulation of miRNA 21 in cells of ESCC cell lines and inhibited cell proliferation, migration, and invasion. miRNA 21 overexpression failed to affect lncRNA HAND2 AS1 expression but significantly attenuated the inhibitory effect of lncRNA HAND2 AS1 overexpression on cancer cell proliferation, migration, and invasion.
Pubmed ID	30520131
Year	2018
Title	Long noncoding RNA HAND2 AS1 inhibits cancer cell proliferation, migration, and invasion in esophagus squamous cell carcinoma by regulating microRNA 21

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