Basic Information
| LncRNA/CircRNA Name | HAND2-AS1 |
| Synonyms | long non-coding RNA heart and neural crest derivatives expressed 2-antisense RNA 1 |
| Region | GRCh38_4:173527270-173659696 |
| Ensemble | ENSG00000237125 |
| Refseq | NR_136192 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot etc |
| Sample | triple-negative breast cancer tumor tissues, cell lines(MDA-MB-231 and BT-20) |
| Expression Pattern | down-regulated |
| Function Description | Compared with levels in adjacent healthy tissues, expression levels of lncRNA HAND2-AS1 were significantly downregulated. |
| Pubmed ID | 31788122 |
| Year | 2019 |
| Title | Long non-coding RNA heart and neural crest derivatives expressed 2-antisense RNA 1 overexpression inhibits the proliferation of cancer cells by reducing RUNX2 expression in triple-negative breast cancer |
External Links
| Links for HAND2-AS1 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |