Basic Information
| LncRNA/CircRNA Name | HAND2-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:173527270-173659696 |
| Ensemble | ENSG00000237125 |
| Refseq | NR_136192 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Western blot |
| Sample | liver cancer tissues,cell lines(Hep3B, BEL-7402, HepG2, and Huh-7) |
| Expression Pattern | down-regulated |
| Function Description | HAND2-AS1 augmentation apparently impaired the capacity of liver cancer viability, proliferation, and migration. HAND2-AS1 enhanced inactivation of the JAK-STAT pathway through sponging miR-3118 and facilitating SOCS5 to retard cell proliferation and migration in liver cancer. |
| Pubmed ID | 32155348 |
| Year | 2020 |
| Title | lncRNA HAND2-AS1 Inhibits Liver Cancer Cell Proliferation and Migration by Upregulating SOCS5 to Inactivate the JAK-STAT Pathway |
External Links
| Links for HAND2-AS1 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |