Basic Information
| LncRNA/CircRNA Name | AK027294 |
| Synonyms | WISP1, CCN4, WISP1c, WISP1i, WISP1tc |
| Region | GRCh38_8:133191039-133231690 |
| Ensemble | ENSG00000104415 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | glycyrrhiza glabra | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qRT-PCR , Western blot , RNAi , in vitro knockdown etc. |
| Sample | human nasopharyngeal carcinoma cell line, C666-1 |
| Expression Pattern | down-regulated |
| Function Description | AK027294 had a strongest down-regulation upon G. glabra treatment. Knockdown of AK027294 suppresses the proliferation of C666-1 cells by inducing the apoptosis.Moreover, either G. glabra treatment or knockdown of AK027294 significantly increases the production of EZH1 (Enhancer of zeste 1 polycomb repressive complex 2 subunit). |
| Pubmed ID | 31589096 |
| Year | 2019 |
| Title | Glycyrrhiza glabra?Suppresses Nasopharyngeal Carcinoma Cell Proliferation Through Inhibiting the Expression of lncRNA, AK027294 |
External Links
| Links for AK027294 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |