Basic Information
| LncRNA/CircRNA Name | HAGLROS |
| Synonyms | NA |
| Region | GRCh38_2:176177717-176179008 |
| Ensemble | ENSG00000226363 |
| Refseq | NR_110457 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | mantle cell lymphoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | mantle cell lymphoma cell lines of Z-138, Mino, REC-1, Jeko-1, and JVM2, Normal B lymphocytes |
| Expression Pattern | up-regulated |
| Function Description | HAGLROS level was high in mantle cell lymphoma cell lines. Silencing of HAGLROS inhibited Mino cell viability, increased apoptosis and decreased autophagy by sponging miR-100. Moreover, miR-100 targeted ATG5 fixed. Furthermore, HAGLROS suppression resulted in inhibition on the briskness of PI3K/ AKT/mTOR signals. Concurrently HAGLROS suppression and miR-100 inhibitor markedly changed the impacts of HAGLROS down-regulation alone on activating PI3K/AKT/mTOR signals, which could further change after co-transfection of si-HAGLROS t miR-100 inhibitor t siATG5. |
| Pubmed ID | 31498006 |
| Year | 2019 |
| Title | Long noncoding RNA HAGLROS promotes the process of mantle cell lymphoma by regulating miR-100/ATG5 axis and involving in PI3K/AKT/mTOR signal |
External Links
| Links for HAGLROS | GenBank HGNC NONCODE |
| Links for mantle cell lymphoma | OMIM COSMIC |